Travels with ubiquitin: from protein degradation to DNA repair
نویسنده
چکیده
Figure 1. ‘Proteolytic’ and ‘non-proteolytic’ ubiquitin modifications in health and disease. Proteins modified by specific (e.g. lysine-48-linked) poly-ubiquitin chains (red) are normally targeted to degradation. ‘Non-proteolytic’ ubiquitin modifications are mono-ubiquitin and a non-canonical (lysine-63-linked) poly-ubiquitin chain. Malfunctions of the respective pathways can cause numerous human diseases of which selected ones are listed. » I watched out for emerging fields in eukaryotic biology and for people who ask the most interesting questions. «
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2011